Variations in Mitochondrial Respiration Differ in IL-1ß/IL-10 Ratio Based Subgroups in Autism Spectrum Disorders
Jyonouchi H, Geng L, Rose S, Bennuri SC, Frye RE. Variations in Mitochondrial Respiration Differ...
Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder
Scientific ArticlesAcyl-Carnitine,Autism,Biomarkers,Environmental Factors,Mitochondrial Dysfunction,Published Articles
Frye, R., Melnyk, S. & MacFabe, D. Unique acyl-carnitine profiles are potential biomarkers for acquired...
Treatments for biomedical abnormalities associated with autism spectrum disorder
Frye RE, Rossignol DA. Treatments for biomedical abnormalities associated with autism spectrum disorder. Front Pediatr...
Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder
Rossignol DA, Frye RE. Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid)...
Treatment for Sleep Problems in Children with Autism and Caregiver Spillover Effects
Tilford JM, Payakachat N, Kuhlthau KA, Pyne JM, Kovacs E, Bellando J, Williams DK, Brouwer...
Transgenerational Effects and Heritability of Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorder
Frye, R.E.; Cohen, I.L.; Sequeira, J.M.; Hill, Z.; Espinoza, A.; Brown, W.T.; Mevs, C.; Marchi...
Transdermal Electrical Neuromodulation for Anxiety and Sleep Problems in High-Functioning Autism Spectrum Disorder: Feasibility and Preliminary Findings
Foldes ST, Jensen AR, Jacobson A, Vassall S, Foldes E, Guthery A, Brown D, Levine...
Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey
Frye RE, Sreenivasula S, Adams JB. Traditional and non-traditional treatments for autism spectrum disorder with...
Tract-based spatial statistics reveal altered relationship between non-verbal reasoning abilities and white matter integrity in autism spectrum disorder
Ellmore TM, Li H, Xue Z, Wong ST, Frye RE. Tract-based spatial statistics reveal altered...
Touch, sound and vision in human superior temporal sulcus
Beauchamp MS, Yasar NE, Frye RE, Ro T. Touch, sound and vision in human superior...
Time dependent changes in the bioenergetics of peripheral blood mononuclear cells: processing time, collection tubes and cryopreservation effects
Werner BA, McCarty PJ, Lane AL, Singh I, Karim MA, Rose S, Frye RE. Time...
The Soluble Folate Receptor in Autism Spectrum Disorder: Relation to Autism Severity and Leucovorin Treatment.
Scientific ArticlesAutism,Biomarkers,Cerebral Folate Deficiency,Metabolism,Mitochondrial Dysfunction,Published Articles
Frye RE, Lane A, Worner A, Werner BA, McCarty PJ, Scheck AC, Collins HL, Adelman...
The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood
Slattery J, MacFabe DF, Frye RE. The Significance of the Enteric Microbiome on the Development...
The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
Scientific ArticlesAutism,Biomarkers,Cobalamin,Folate,Meta-Analysis,Metabolism,Published Articles,Treatment
Rossignol DA, Frye RE. The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A...
The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder
Delhey, L.M.; Nur Kilinc, E.; Yin, L.; Slattery, J.C.; Tippett, M.L.; Rose, S.; Bennuri, S.C.;...
Tetrahydrobiopterin as a novel therapeutic intervention for autism
Frye RE, Huffman LC, Elliott GR. Tetrahydrobiopterin as a novel therapeutic intervention for autism. Neurotherapeutics...
Synchrony 2022: Epilepsy and Seizures in Autism Spectrum Disorder Roundtable
Frye, R.E.; Nanda, H.; Pleasure, S.J.; Casanova, M.F.; Boles, R.G.; Lewine, J.; Gaitanis, J.; Adams...
Synchrony 2022: Catalyzing Research and Treatments to Benefit Individuals with Neurodevelopmental Disorders including Autism Spectrum Disorders
Scientific ArticlesAutism,Biomarkers,Environmental Factors,Immune Dysfunction,Microbiome,Mitochondrial Dysfunction,Published Articles,Treatment
Frye, R.E.; Nanda, H.; Pleasure, S.J.; Casanova, M.F.; Boles, R.G.; Lewine, J.; Gaitanis, J.; Adams...
Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI)
Leon-Carrion J, Leon-Dominguez U, Pollonini L, Wu MH, Frye RE, Dominguez-Morales MR, Zouridakis G. Synchronization...
Surface Area Accounts for the Relation of Gray Matter Volume to Reading-Related Skills and History of Dyslexia
Frye RE, Liederman J, Malmberg B, McLean J, Strickland D, Beauchamp MS. Surface area accounts...
Superior longitudinal fasciculus and cognitive dysfunction in adolescents born preterm and at term
Frye RE, Hasan K, Malmberg B, Desouza L, Swank P, Smith K, Landry S. Superior...
Substantial problems with measuring brain mitochondrial dysfunction in autism spectrum disorder using magnetic resonance spectroscopy
Scientific ArticlesAutism,Biomarkers,Magnetic Resonance Spectroscopy,Mitochondrial Dysfunction,Published Articles
Rossignol, D.A., Frye, R.E. Substantial Problems with Measuring Brain Mitochondrial Dysfunction in Autism Spectrum Disorder...
Splenium microstructure is related to two dimensions of reading skill
Frye RE, Hasan K, Xue L, Strickland D, Malmberg B, Liederman J, Papanicolaou A. Splenium...
Social Skills Deficits in Autism Spectrum Disorder: Potential Biological Origins and Progress in Developing Therapeutic Agents
Frye RE. Social Skills Deficits in Autism Spectrum Disorder: Potential Biological Origins and Progress in...
Serum microRNAs in ASD: Association With Monocyte Cytokine Profiles and Mitochondrial Respiration
Jyonouchi H, Geng L, Toruner GA, Rose S, Bennuri SC, Frye RE. Serum microRNAs in...
Seizures in Fragile X Syndrome: Associations and Longitudinal Analysis of a Large Clinic-Based Cohort.
Berry-Kravis E, Filipink RA, Frye RE, Golla S, Morris SM, Andrews H, Choo TH, Kaufmann...
Reversible posterior leukoencephalopathy syndrome in sickle-cell anemia
Frye RE. Reversible posterior leukoencephalopathy syndrome in sickle-cell anemia. Pediatr Neurol. 2009 Apr;40(4):298-301. doi: 10.1016/j.pediatrneurol.2008.10.024...
Resting State Functional Magnetic Resonance Imaging Elucidates Neurotransmitter Deficiency in Autism Spectrum Disorder
Scientific ArticlesAutism,Magnetic Resonance Spectroscopy,Neuroimaging,Neurotransmitters,Published Articles
McCarty PJ, Pines AR, Sussman BL, Wyckoff SN, Jensen A, Bunch R, Boerwinkle VL, Frye...
Reliability of the Cunningham Panel
Frye RE, Shimasaki C. Reliability of the Cunningham Panel. Translational Psychiatry. 2019 Apr;9(1):129. DOI: 10.1038/s41398-019-0462-1...
Redox Metabolism Abnormalities in Autistic Children Associated with Mitochondrial Disease
Scientific ArticlesAutism,Biomarkers,Metabolism,Mitochondrial Dysfunction,Published Articles,Treatment
Frye, R., DeLaTorre, R., Taylor, H. et al. Redox metabolism abnormalities in autistic children associated...
Receptive language organization in high-functioning autism
Frye RE, Beauchamp MS. Receptive language organization in high-functioning autism. J Child Neurol. 2009 Feb;24(2):231-6...
Reanalysis of Trio Whole-Genome Sequencing Data Doubles the Yield in Autism Spectrum Disorder: De Novo Variants Present in Half
Omri Bar , Elizabeth Vahey , Mark Mintz , Richard E. Frye , Richard G...
Ratings of the Effectiveness of Nutraceuticals for Autism Spectrum Disorders: Results of a National Survey
Adams, J.B.; Bhargava, A.; Coleman, D.M.; Frye, R.E.; Rossignol, D.A. Ratings of the Effectiveness of...
Rating of the Effectiveness of 26 Psychiatric and Seizure Medications for Autism Spectrum Disorder: Results of a National Survey
Coleman DM, Adams JB, Anderson AL, Frye RE. Rating of the Effectiveness of 26 Psychiatric...
Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder
Zimmerman AW, Singh K, Connors SL, Liu H, Panjwani AA, Lee LC, Diggins E, Foley...
Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment
Niyazov DM, Kahler SG, Frye RE. Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of...
Preterm birth and maternal responsiveness during childhood are associated with brain morphology in adolescence
Frye RE, Malmberg B, Swank P, Smith K, Landry S. Preterm birth and maternal responsiveness...
PREPRINT: High Sensitivity for Detection of Primary Diagnostic Variants in Autism, Including De Novo Variants, with Trio Whole Genome Sequencing and Data Reanalysis
Omri Bar , Elizabeth Vahey , Mark Mintz , Richard E. Frye , Richard G...
Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology
Scientific ArticlesAutism,Environmental Factors,Methylation,Mitochondrial Dysfunction,PBMCs,Physiological Mediators,Prenatal,Published Articles,Redox,Regression
Frye RE, Cakir J, Rose S, Delhey L, Bennuri SC, Tippett M, Melnyk S, James...
Physiological mediators of prenatal environmental influences in autism spectrum disorder
Scientific ArticlesAutism,Environmental Factors,Immune Dysfunction,Metabolism,Methylation,Physiological Mediators,Prenatal,Published Articles,Redox
Frye RE, Cakir J, Rose S, Palmer RF, Austin C, Curtin P. Physiological mediators of...
Peripheral Blood Mononuclear Cell Oxytocin and Vasopressin Receptor Expression Positively Correlates with Social and Behavioral Function in Children with Autism
Voinsky, I., Bennuri, S.C., Svigals, J. et al. Peripheral Blood Mononuclear Cell Oxytocin and Vasopressin...
Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society
Parikh S, Goldstein A, Karaa A, Koenig MK, Anselm I, Brunel-Guitton C, Christodoulou J, Cohen...
Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort
Scientific ArticlesAutism,Lymphoblastoid Cell Lines,Mitochondrial Dysfunction,Oxidative Stress,Published Articles
Rose S, Frye RE, Slattery J, Wynne R, Tippett M, Pavliv O, Melnyk S, James...
Oxidative Stress Challenge Uncovers Trichloroacetaldehyde Hydrate-Induced Mitoplasticity in Autistic and Control Lymphoblastoid Cell Lines
Scientific ArticlesAutism,Lymphoblastoid Cell Lines,Mitochondrial Dysfunction,Oxidative Stress,Published Articles
Frye, R.E., Rose, S., Wynne, R. et al. Oxidative Stress Challenge Uncovers Trichloroacetaldehyde Hydrate-Induced Mitoplasticity...
Objective Phonological and Subjective Perceptual Characteristics of Syllables Modulate Spatiotemporal Patterns of Superior Temporal Gyrus Activity
Frye RE, Fisher JM, Witzel T, Ahlfors SP, Swank P, Liederman J, Halgren E. Objective...
Nuclear Peroxisome Proliferator-Activated Receptors (PPARs) as Therapeutic Targets of Resveratrol for Autism Spectrum Disorder
Barone R, Rizzo R, Tabbì G, Malaguarnera M, Frye RE, Bastin J. Nuclear Peroxisome Proliferator-Activated...
Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers
Khemakhem, A.M., Frye, R.E., El-Ansary, A. et al. Novel biomarkers of metabolic dysfunction is autism...
Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder
Frye RE, Casanova MF, Fatemi SH, Folsom TD, Reutiman TJ, Brown GL, Edelson SM, Slattery...
Network‐based analysis reveals stronger local diffusion‐based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders
Li H, Xue Z, Ellmore TM, Frye RE, Wong ST. Network-based analysis reveals stronger local...
Multivariate techniques enable a biochemical classification of children with autism spectrum disorder versus typically-developing peers: A comparison and validation study
Howsmon DP, Vargason T, Rubin RA, Delhey L, Tippett M, Rose S, Bennuri SC, Slattery...
Multichannel least-squares linear regression provides a fast, accurate, unbiased and robust estimation of Granger causality for neurophysiological data
Frye RE, Wu MH. Multichannel least-squares linear regression provides a fast, accurate, unbiased and robust...
Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines
Scientific ArticlesAutism,Environmental Factors,Immune Dysfunction,Lymphoblastoid Cell Lines,Mitochondrial Dysfunction,Oxidative Stress,Published Articles
Frye RE, Rose S, Chacko J, Wynne R, Bennuri SC, Slattery JC, Tippett M, Delhey...
Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid
Scientific ArticlesAutism,Environmental Factors,Immune Dysfunction,Lymphoblastoid Cell Lines,Mitochondrial Dysfunction,Published Articles
Frye RE, Nankova B, Bhattacharyya S, Rose S, Bennuri SC, MacFabe DF. Front Immunol. 2017...
Modern Biomarkers for Autism Spectrum Disorder: Future Directions
Jensen AR, Lane AL, Werner BA, McLees SE, Fletcher TS, Frye RE. Modern Biomarkers for...
Mitochondrial Supplement Improves Function and Mitochondrial Activity in Autism: A Double-Blind Placebo-Controlled Cross-Over Trial
Hill, Z.; McCarty, P.J.; Boles, R.G.; Frye, R.E. A Mitochondrial Supplement Improves Function and Mitochondrial...
Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder
Frye RE, Lionnard L, Singh I, Karim MA, Chajra H, Frechet M, Kissa K, Racine...
Mitochondrial Fatty Acid β-Oxidation and Resveratrol Effect in Fibroblasts from Patients with Autism Spectrum Disorder
Barone R, Bastin J, Djouadi F, Singh I, Karim MA, Ammanamanchi A, McCarty PJ, Delhey...
Mitochondrial Dysfunction may explain symptom variation in Phelan-McDermid Syndrome
Frye, R., Cox, D., Slattery, J. et al. Mitochondrial Dysfunction may explain symptom variation in...
Mitochondrial Dysfunction Is Inducible in Lymphoblastoid Cell Lines From Children With Autism and May Involve the TORC1 Pathway
Scientific ArticlesAutism,Lymphoblastoid Cell Lines,Mitochondrial Dysfunction,Published Articles,Treatment
Bennuri SC, Rose S, Frye RE. Mitochondrial Dysfunction Is Inducible in Lymphoblastoid Cell Lines From...
Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study
Rose S, Bennuri SC, Murray KF, Buie T, Winter H, Frye RE. Mitochondrial dysfunction in...
Mitochondrial Dysfunction in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis
Rossignol, D., Frye, R. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis...
Mitochondrial Dysfunction in Autism Spectrum Disorder: Unique Abnormalities and Targeted Treatments
Frye RE. Mitochondrial Dysfunction in Autism Spectrum Disorder: Unique Abnormalities and Targeted Treatments. Semin Pediatr...
Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders
Frye, R., Rossignol, D. Mitochondrial Dysfunction Can Connect the Diverse Medical Symptoms Associated With Autism...
Mitochondrial disease in 22q13 duplication syndrome
Frye RE. Mitochondrial disease in 22q13 duplication syndrome. J Child Neurol. 2012 Jul;27(7):942-9. doi: 10.1177/0883073811429858...
Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study
Scientific ArticlesAutism,Lymphoblastoid Cell Lines,Mitochondrial Dysfunction,Published Articles,Redox
Rose S, Bennuri SC, Wynne R, Melnyk S, James SJ, Frye RE. Mitochondrial and redox...
Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder
Scientific ArticlesAutism,Environmental Factors,Methylation,Mitochondrial Dysfunction,Physiological Mediators,Prenatal,Published Articles,Redox,Regression
Frye RE, Cakir J, Rose S, Palmer RF, Austin C, Curtin P, Arora M. Mitochondria...
MicroRNA Expression Profiles in Autism Spectrum Disorder: Role for miR-181 in Immunomodulation
Frye RE, Rose S, McCullough S, Bennuri SC, Porter-Gill PA, Dweep H, Gill PS. MicroRNA...
Metabolomic Signatures of Autism Spectrum Disorder
Brister D, Rose S, Delhey L, Tippett M, Jin Y, Gu H, Frye RE. Metabolomic...
Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study
Frye RE, DeLatorre R, Taylor HB, Slattery J, Melnyk S, Chowdhury N, James SJ. Metabolic...
Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder
Frye RE. Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder...
Melatonin in autism spectrum disorders: a systematic review and meta-analysis
Rossignol DA, Frye RE. Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev...
Long COVID Syndrome Presenting as Neuropsychiatric Exacerbations in Autism Spectrum Disorder: Insights for Treatment
Jyonouchi, H.; Geng, L.; Rossignol, D.A.; Frye, R.E. Long COVID Syndrome Presenting as Neuropsychiatric Exacerbations...
Locked-in Intact Functional Networks in Children with Autism Spectrum Disorder: A Case-Control Study
Pines AR, Sussman B, Wyckoff SN, McCarty PJ, Bunch R, Frye RE, Boerwinkle VL. Locked-in...
Linear coding of voice onset time
Frye RE, Fisher JM, Coty A, Zarella M, Liederman J, Halgren E. Linear coding of...
Laterality of temporoparietal causal connectivity during the prestimulus period correlates with phonological decoding task performance in dyslexic and typical readers
Frye RE, Liederman J, McGraw Fisher J, Wu MH. Laterality of temporoparietal causal connectivity during...
Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism
Scientific ArticlesAutism,Biomarkers,Immune Dysfunction,IVIG,Metabolism,Published Articles,Treatment
Connery K, Tippett M, Delhey LM, Rose S, Slattery JC, Kahler SG, Hahn J, Kruger...
Integrated microRNA–mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism
Gill, P.S.; Dweep, H.; Rose, S.; Wickramasinghe, P.J.; Vyas, K.K.; McCullough, S.; Porter-Gill, P.A.; Frye...
Inheritance of HLA-Cw7 Associated With Autism Spectrum Disorder (ASD)
Harville T, Rhodes-Clark B, Bennuri SC, Delhey L, Slattery J, Tippett M, Wynne R, Rose...
Information communication networks in severe traumatic brain injury
Pollonini L, Pophale S, Situ N, Wu MH, Frye RE, Leon-Carrion J, Zouridakis G. Information...
Increased prefrontal activation in adolescents born prematurely at high risk during a reading task
Frye RE, Malmberg B, Desouza L, Swank P, Smith K, Landry S. Increased prefrontal activation...
Increased left prefrontal activation during an auditory language task in adolescents born preterm at high risk
Frye RE, Malmberg B, McLean J 3rd, Swank P, Smith K, Papanicolaou A, Landry S...
Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes
Frye RE, Rossignol DA. Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to...
Human brain atlas-based volumetry and relaxometry: application to healthy development and natural aging
Hasan KM, Walimuni IS, Kramer LA, Frye RE. Human brain atlas-based volumetry and relaxometry: application...
Greater Pre-Stimulus Effective Connectivity from the Left Inferior Frontal Area to other Areas is Associated with Better Phonological Decoding in Dyslexic Readers
Frye RE, Wu MH, Liederman J, Fisher JM. Greater Pre-Stimulus Effective Connectivity from the Left...
Global cerebral and regional multimodal neuroimaging markers of the neurobiology of autism: development and cognition
Hasan KM, Walimuni IS, Frye RE. Global cerebral and regional multimodal neuroimaging markers of the...
Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome
Richard E. Frye, Shannon Rose, John Slattery & Derrick F. MacFabe (2015) Gastrointestinal dysfunction in...
Functional Neuroimaging of Language Using Magnetoencephalography
Frye RE, Rezaie R, Papanicolaou AC. Functional Neuroimaging of Language Using Magnetoencephalography. Phys Life Rev...
Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial
Frye RE, Slattery J, Delhey L, Furgerson B, Strickland T, Tippett M, Sailey A, Wynne...
Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population
Wells, L.; O’Hara, N.; Frye, R.E.; Hullavard, N.; Smith, E. J. Pers. Med. 2024...
Folate metabolism abnormalities in autism: potential biomarkers
Frye RE, Slattery JC, Quadros EV. Folate metabolism abnormalities in autism: potential biomarkers. Biomark Med...
Feeding-Related Early Signs of Autism Spectrum Disorder: A Narrative Review
Castro K, Frye RE, Silva E, Vasconcelos C, Hoffmann L, Riesgo R, Vaz J. 3...
Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism
Scientific ArticlesAutism,Immune Dysfunction,Metabolism,Mitochondrial Dysfunction,Oxidative Stress,Published Articles
Rossignol DA, Frye RE. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain...
Evaluation of the Cunningham Panel™ in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in
Scientific ArticlesAutism,Cunningham Panel,Immune Dysfunction,PANDAS,PANS,Published Articles,Treatment
Shimasaki C, Frye RE, Trifiletti R, Cooperstock M, Kaplan G, Melamed I, Greenberg R, Katz...
Environmental toxicants and autism spectrum disorders: a systematic review
Rossignol DA, Genuis SJ, Frye RE. Environmental toxicants and autism spectrum disorders: a systematic review...
Entorhinal Cortex Thickness across the Human Lifespan
Hasan KM, Mwangi B, Cao B, Keser Z, Tustison NJ, Kochunov P, Frye RE, Savatic...
Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored?
Slattery J, MacFabe DF, Kahler SG, Frye RE. Enteric Ecosystem Disruption in Autism Spectrum Disorder:...
Emerging biomarkers in autism spectrum disorder: a systematic review
Frye RE, Vassall S, Kaur G, Lewis C, Karim M, Rossignol D. Emerging biomarkers in...
Electroencephalogram discharges in atypical cognitive development
Frye RE, Butler I, Strickland D, Castillo E, Papanicolaou A. Electroencephalogram discharges in atypical cognitive...
Effectiveness of methylcobalamin and folinic Acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status
Frye RE, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor...
Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder
Scientific ArticlesAutism,Environmental Factors,Metals,Mitochondrial Dysfunction,PBMCs,Physiological Mediators,Published Articles,Redox,Regression
Frye RE, Cakir J, Rose S, Delhey L, Bennuri SC, Tippett M, Palmer RF, Austin...
Diffusion tensor‐based regional gray matter tissue segmentation using the international consortium for brain mapping atlases
Hasan KM, Frye RE. Diffusion tensor-based regional gray matter tissue segmentation using the international consortium...
Diffusion tensor tractography of the human brain cortico-ponto-cerebellar pathways: a quantitative preliminary study
Kamali A, Kramer LA, Frye RE, Butler IJ, Hasan KM. Diffusion tensor tractography of the...
Diffusion tensor quantification of the relations between microstructural and macrostructural indices of white matter and reading
Frye RE, Liederman J, Hasan KM, Lincoln A, Malmberg B, McLean J 3rd, Papanicolaou A...
Developmental regression and mitochondrial function in children with autism
Singh K, Singh IN, Diggins E, Connors SL, Karim MA, Lee D, Zimmerman AW, Frye...
Developmental regression and mitochondrial dysfunction in a child with autism
Poling, J. S., Frye, R. E., Shoffner, J., & Zimmerman, A. W. (2006). Developmental regression...
De Novo Variants Predominate in Autism Spectrum Disorder
Boles, R.G.; Bar, O.; Boles, P.T.; Hill, Z.R.; Frye, R.E. De Novo Variants Predominate in...
Comparison of Treatment for Metabolic Disorders Associated with Autism:Reanalysis of Three Clinical Trials
Delhey LM, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ, Frye...
Clinical potential, safety, and tolerability of arbaclofen in the treatment of autism spectrum disorder
Frye RE. Clinical potential, safety, and tolerability of arbaclofen in the treatment of autism spectrum...
Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder
Scientific ArticlesAutism,Biomarkers,Metabolism,Mitochondrial Dysfunction,Published Articles,Treatment
Rose S, Niyazov DM, Rossignol DA, Goldenthal M, Kahler SG, Frye RE. Clinical and Molecular...
Choroid plexus papilloma expansion over 7 years in Aicardi syndrome
Frye RE, Polling JS, Ma LC. Choroid plexus papilloma expansion over 7 years in Aicardi...
Cerebral folate receptor autoantibodies in autism spectrum disorder
Scientific ArticlesAutism,Cerebral Folate Deficiency,Folate,FRA Antibodies,Leucovorin,Published Articles,Treatment
Frye RE, Sequeira JM, Quadros EV, James SJ, Rossignol DA. Cerebral folate receptor autoantibodies in...
Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis
Scientific ArticlesAutism,Cerebral Folate Deficiency,Folate,Leucovorin,Meta-Analysis,Published Articles,Treatment
Rossignol DA, Frye RE. Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid)...
Central Nervous System Metabolism in Autism, Epilepsy and Developmental Delays: A Cerebrospinal Fluid Analysis
Brister D, Werner BA, Gideon G, McCarty PJ, Lane A, Burrows BT, McLees S, Adelson...
Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism
Scientific ArticlesAutism,Environmental Factors,Lymphoblastoid Cell Lines,Microbiome,Mitochondrial Dysfunction,Oxidative Stress,Published Articles
Rose S, Bennuri SC, Davis JE, Wynne R, Slattery JC, Tippett M, Delhey L, Melnyk...
Blood RNA Sequencing Indicates Upregulated BATF2 and LY6E and Downregulated ISG15 and MT2A Expression in Children with Autism Spectrum Disorder
Voinsky, I.; Zoabi, Y.; Shomron, N.; Harel, M.; Cassuto, H.; Tam, J.; Rose, S.; Scheck...
Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis
Frye RE, Rincon N, Mccarty PJ, Brister D, Scheck AC, Rossignol DA. Neurobiology of Disease...
Bioenergetic variation is related to autism symptomatology
Delhey L, Kilinc EN, Yin L, Slattery J, Tippett M, Wynne R, Rose S, Kahler...
Bioenergetic Signatures of Neurodevelopmental Regression
Frye RE, Mccarty PJ, Werner BA, Rose S, Scheck A. Front. Physiol. Sec. Mitochondrial Research...
Biochemical, Genetic and Clinical Diagnostic Approaches to Autism-Associated Inherited Metabolic Disorders
Senarathne, U.D.; Indika, N.-L.R.; Jezela-Stanek, A.; Ciara, E.; Frye, R.E.; Chen, C.; Stepien, K.M. Biochemical...
Binding Folate Receptor Alpha Autoantibody Is a Biomarker for Leucovorin Treatment Response in Autism Spectrum Disorder
Frye RE, McCarty PJ, Werner BA, Scheck AC, Collins HL, Adelman SJ, Rossignol DA, Quadros...
Autistic Siblings with Novel Mutations in Two Different Genes: Insight for Genetic Workups of Autistic Siblings and Connection to Mitochondrial Dysfunction
Scientific ArticlesAutism,Magnetic Resonance Spectroscopy,Mitochondrial Dysfunction,Published Articles,Treatment
Burger BJ, Rose S, Bennuri SC, et al. Autistic Siblings with Novel Mutations in Two...
Association With Monocyte Cytokine Profiles and Mitochondrial Respiration
Scientific ArticlesAutism,Biomarkers,Immune Dysfunction,Mitochondrial Dysfunction,Published Articles
Jyonouchi H, Geng L, Toruner GA, Rose S, Bennuri SC, Frye RE. Serum microRNAs in...
Approaches to studying and manipulating the enteric microbiome to improve autism symptoms
Frye RE, Slattery J, MacFabe DF, Allen-Vercoe E, Parker W, Rodakis J, Adams JB, Krajmalnik-Brown...
Air Pollution and Maximum Temperature Are Associated with Neurodevelopmental Regressive Events in Autism Spectrum Disorder
Frye RE, Cakir J, McCarty PJ, Rose S, Delhey LM, Palmer RF, Austin C, Curtin...
A Systematic Review and Meta-Analysis of Immunoglobulin G Abnormalities and the Therapeutic Use of Intravenous Immunoglobulins (IVIG) in Autism Spectrum Disorder
Scientific ArticlesAutism,Biomarkers,Immune Dysfunction,IVIG,Meta-Analysis,Metabolism,Published Articles
Rossignol DA, Frye RE. A Systematic Review and Meta-Analysis of Immunoglobulin G Abnormalities and the...
A Subset of Patients With Autism Spectrum Disorders Show a Distinctive Metabolic Profile by Dried Blood Spot Analyses
Barone R, Alaimo S, Messina M, Pulvirenti A, Bastin J; MIMIC-Autism Group; Ferro A, Frye...
A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel
Frye RE, Rossignol D, Casanova MF, Brown GL, Martin V, Edelson S, Coben R, Lewine...
A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures
Rossignol DA, Frye RE. A review of research trends in physiological abnormalities in autism spectrum...
A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder
Frye RE. A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder. J Pers...
A lack of statistical pitfalls in the comparison of multivariate causality measures for effective causality
Frye RE. A lack of statistical pitfalls in the comparison of multivariate causality measures for...
A comparison of multivariate causality based measures of effective connectivity
Wu MH, Frye RE, Zouridakis G. A comparison of multivariate causality based measures of effective...
A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women
Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams...
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