De Novo Variants Predominate in Autism Spectrum Disorder
Boles, R.G.; Bar, O.; Boles, P.T.; Hill, Z.R.; Frye, R.E. De Novo Variants Predominate in Autism Spectrum Disorder. Genes 2025, 16, 1099.
Scientific Articles
Biomarkers
Scientific Articles
Mitochondrial Supplement Improves Function and Mitochondrial Activity in Autism: A Double-Blind Placebo-Controlled Cross-Over Trial
Hill, Z.; McCarty, P.J.; Boles, R.G.; Frye, R.E. A Mitochondrial Supplement Improves Function and Mitochondrial Activity in Autism: A Double-Blind Placebo-Controlled Cross-Over Trial. Int. J. Mol. Sci. 2025, 26, 2479.
Scientific Articles
Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis
Frye RE, Rincon N, Mccarty PJ, Brister D, Scheck AC, Rossignol DA. Neurobiology of Disease. 3 May 2024. https://doi.org/10.1016/j.nbd.2024.106520
Scientific Articles
Bioenergetic Signatures of Neurodevelopmental Regression
Frye RE, Mccarty PJ, Werner BA, Rose S, Scheck A. Front. Physiol. Sec. Mitochondrial Research. Vol 15 -2024. doi: 10.3389/fphys.2024.1306038
Scientific Articles
Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population
Wells, L.; O’Hara, N.; Frye, R.E.; Hullavard, N.; Smith, E. J. Pers. Med. 2024, 14, 166.
Scientific Articles
Binding Folate Receptor Alpha Autoantibody Is a Biomarker for Leucovorin Treatment Response in Autism Spectrum Disorder
Frye RE, McCarty PJ, Werner BA, Scheck AC, Collins HL, Adelman SJ, Rossignol DA, Quadros EV. J Pers Med. 1 Jan 2024.
Scientific Articles
Reanalysis of Trio Whole-Genome Sequencing Data Doubles the Yield in Autism Spectrum Disorder: De Novo Variants Present in Half
Omri Bar , Elizabeth Vahey , Mark Mintz , Richard E. Frye , Richard G. Boles. International Journal of Molecular Sciences. 18 Jan 2024.
Scientific Articles
PREPRINT: High Sensitivity for Detection of Primary Diagnostic Variants in Autism, Including De Novo Variants, with Trio Whole Genome Sequencing and Data Reanalysis
Omri Bar , Elizabeth Vahey , Mark Mintz , Richard E. Frye , Richard G. Boles. Preprints.org. 14 Aug 2023.
Scientific Articles
Synchrony 2022: Catalyzing Research and Treatments to Benefit Individuals with Neurodevelopmental Disorders including Autism Spectrum Disorders
Frye, R.E.; Nanda, H.; Pleasure, S.J.; Casanova, M.F.; Boles, R.G.; Lewine, J.; Gaitanis, J.; Adams, J.B. Synchrony 2022: Epilepsy and Seizures in Autism Spectrum Disorder Roundtable. J. Pers. Med. 2023, 13, 557. https://doi.org/10.3390/jpm13030557
Scientific Articles
Biochemical, Genetic and Clinical Diagnostic Approaches to Autism-Associated Inherited Metabolic Disorders
Senarathne, U.D.; Indika, N.-L.R.; Jezela-Stanek, A.; Ciara, E.; Frye, R.E.; Chen, C.; Stepien, K.M. Biochemical, Genetic and Clinical Diagnostic Approaches to Autism-Associated Inherited Metabolic Disorders. Genes 2023, 14, 803. https://doi.org/10.3390/genes14040803